Clinical Pharmacology & Experimental Therapeutics Center | Texas Tech University Health Sciences Center


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Clinical Pharmacology & Experimental Therapeutics Center

The center provides pharmaceutical expertise to conduct and support preclinical and clinical/translational trials, and postmarketing assessment of pharmaceutical drugs. The Clinical Pharmacology & Experimental Therapeutics Center consists of four core areas of focused research:

  • Pediatric Pharmacology Research & Development Core
  • Experimental Therapeutics Core
  • North Texas Clinical Pharmacology Cancer Core (funded in part by the Cancer Prevention and Research Institute of Texas)
  • Pharmacoepidemiology and Clinical Outcomes Core

 Primary areas of research focus:

  • Pharmacokinetics/Pharmacodynamics
  • Drug metabolism
  • Drug formulation and delivery
  • Biomarker identification
  • Chemical characterization
  • Pharmacoepidemiology and drug safety
  • Clinical Outcomes

Analytical Instrumentation:

The Center鈥檚 analytical laboratory specializes in developing and validating methods for the analysis of both small- and large-molecule pharmaceutical agents, their metabolites, and biomarkers in complex biologic matrices using state-of-the-art bioanalytical techniques.


Faculty Members:



Overall, the Clinical Pharmacology & Experimental Therapeutics Center specializes in conducting pharmacology studies on experimental therapeutics.

Specific capabilities of the Center include:

  • Conduct of Pharmacoepidemiology studies
  • Conduct of Clinical Outcomes studies
  • Bioanalytical method development
  • Bioanalytical method validation
  • Blood/Plasma/Serum sample analysis
  • Tissue sample analysis / tissue distribution analysis
  • Analyte/formulation stability studies
  • Automated sample preparation
  • Small molecule bioanalytical sample analysis
  • Biomolecule bioanalytical sample analysis
  • Metals analysis
  • Pharmacokinetic determinations
  • Targeted metabolite studies
  • Chemical characterization of small molecules, biotherapeutics, formulated products and botanical extracts
  • Regulatory development input

 Additional services provided by Center faculty:

  • Program and protocol development and support
  • Analyses and interpretation of PK and PK/PD data
  • Population PK analysis for optimal dosing


  • Laboratory space: ~2,500 square feet
  • General equipment:  analytical balances, pipettes, pH meters, centrifuges, two Labconco CentriVap庐 systems, two Nitrogen-evaporation systems, two refrigerators (5 卤 3 掳C), two freezers (-20 卤 10 掳C) and four ultra-freezers (-80 卤 10 掳C). The ultra-freezers are continuously monitored and clinical samples are inventoried using FreezerPro庐 software package. Specialized automated sample preparation equipment includes an Eppendorf epMotion M5073 and a Tomtec Quadra 4庐 automated liquid handling systems.
  • Tissue preparation equipment: Pro Scientific DPS-20 homogenization system (ultrasonic and mechanical homogenization); Leica RM2255 microtome, Leica CM3050S Cryostat, and a Leica LMP6 laser microdissection system.
  • Mass spectrometric instrumentation includes: Sciex QTRAP庐 6500+, Sciex QTRAP庐 5500, Sciex TripleTOF鈩 5600, and an Agilent 7700 ICP-MS. The Sciex QTRAP庐and TripleTOF鈩nstruments can be interfaced with Shimadzu Nexera UHPLC systems or Eksigent exspert鈩ano-LC/micro-LC system.  Additional gradient liquid chromatographic (HPLC) systems are available with Shimadzu UV/Vis, ELSD and Dionex electrochemical detectors. Specialized analytical software includes Sciex鈥檚 Analyst鈩, PeakView鈩, SWATH鈩, and MultiQuant鈩 software packages.
  • Pharmacokinetic modeling software: Certara Phoenix 64 WinNonlin v6.4.


Founded in 2004

Located in Dallas Medical District adjacent fo the UT Southwestern Medical Center

Dr. Trey Putnam

William "Trey" Putnam, Ph.D.
Center Director

(214) 358-9018

5920 Forest Park Rd Dallas, TX


Academic pricing is available for research collaborations where the investigators hold primary appointments with institutions of higher education. Due to external funding from the Cancer Prevention & Research Institute of Texas (CPRIT), special pricing is available to support cancer investigations.

Grant and Contract Funding:

Sustained since 2004

Funders: NIH, NICHD, NCI and others

North Texas Clinical Pharmacology Cancer Core: Significant funding has recently been awarded by the Cancer Prevention and Research Institute of Texas (CPRIT) to further develop the core (second 5-year award).

CTSA core facility